is this bluff OK?

Decent enough blockers and he hasn't got many sets/2 pair but depends how questionable the calls were you saw? He's likely to land here with more Qx and more flushes than he should, so it would depend whether he is likely to call off with the 1 pair region.

I'm avoiding to bluff OTR if I Overbet OTT.
Would rather use B25-B75-B100

Bad bluff vs this player. If you have seen V "make questionable calls" it normally means they call too often. Bluffing into a player that calls too often makes it so their bad play of calling too often is rewarded by your bad play of making their call correct. You want to bluff players that do not call enough and value bet players that call too often.

Overbetting on the turn, doesnt make sense for the flush draw on the river. Think its better if lowering down the size 20% or 30% and all in after on the river

1. Why do we mix with big bet on flop ? I would recommend simply to small bet flop or a very exploitive line that is based on mda data but seems like you just try to copy solver am i correct ?

2. I think overbetting turn and goin all in on river is not a great idea here if villain is on the sticky side especialy after that big cb on flop. Try to imagine the weak part of his range and figure out how to bring that part into the toughest spot. For example here as played you could use a 75% on the river to fold out the jx floats.

3. Consider your other options like b x b line or b x and raise his river block on flush runouts or bet vs his very weak checking range on river etc. as better alternatives to bluff that hand

Thanks for the answers !

Indeed. I guessed this flop was a "big bet or check" one. I know most of the time just range betting has the same EV (or even better since I'm likely to do some mistakes trying to do more complex things)

I like the play in every street, think you have perfect combo to bluff the river also.
The problem is villain has pretty strong range after calling big cb on flop and overbet on turn, and if you have seen that he is sticky he might not just able to fold what he is supposed to.

I'm okay with this line and the combo. Don't overdo it though.

I would avoid these types of plays all together at NL10z. Def not worth it. I beat that limit easily without doing anything out of the norm lol just need alot of hands/time

Yea just simplyfie to range bet best i think because then you need much less time to play a solid winning strat. As soon you check you open up so many other trees wich makes things much more complex = much more time needed to become solid.